(P267) TIME-VARYING IMPACT OF RISK FACTORS FOR CORONARY EVENTS AFTER ROBOTIC HYBRID OFF-PUMP CORONARY REVASCULARIZATION

Background: The impact of long-term complications after CABG, including repeat revascularization, myocardial infarction (MI), and persistent angina in patients undergoing robotic hybrid coronary revascularization (HCR) remain limited. In the present study, we sought to determine risk factors for coronary events after robotic HCR and their time-varying effects on outcomes.

METHODS AND RESULTS: We identified all consecutive patients who underwent robotic HCR between February 2006 and June 2021 at our institution. Baseline characteristics were explored as possible risk factors for angina, MI and repeat revascularization with stents at any time during the follow-up after the index procedures.

A total of 875 patients (mean age 71.1±11.1 years) underwent robotic HCR at our institution. After a median follow-up of 3.32 years (IQR 1.18-6.34 years), angina occurred in 134 patients (15.3%), repeat revascularization with stents in 139 patients (15.8%), and MI in 36 patients (4.1%). The hazard rates for all outcomes increased with follow-up time, with a notable early rise around 2 years of follow-up for angina and, to a lesser extent, repeat revascularization. We identified risk factors for events with constant and time-varying effects, including lack of radial artery graft use, black race, diabetes, obesity, chronic obstructive pulmonary disease (COPD), low ejection fraction (EF) 50%), and more than three vessels disease.

Conclusion: More than three vessels disease, severe left main coronary artery stenosis, diabetes, obesity, low EF, and COPD are periprocedural risk factors associated with long-term prognosis in patients undergoing HCR.