(P246) VAPING CESSATION INTERVENTIONS: A SYSTEMATIC REVIEW AND META ANALYSIS

Background: Electronic nicotine delivery systems (ENDS), like e-cigarettes, have surged in popularity. While long-term risks remain unclear, known dangers include nicotine addiction, E-cigarette or Vaping Use-Associated Lung Injury (EVALI), and potential extrapulmonary effects on the heart, immune system, and neurodevelopment. Addressing ENDS addiction may require strategies akin to smoking cessation. However, evidence is lacking; there are no currently approved vaping-cessation aids. The objective of this review is to summarize the available literature addressing interventions for vaping cessation.

METHODS AND RESULTS: A librarian-assisted search was conducted in MEDLINE, Embase, and Scopus, as well as pre-prints in Europe PMC, Open Science Framework, and the grey literature searches. We included randomized controlled trials (RCTs) that examining “rates of vaping cessation” outcomes. Intention-to-treat approach was used for data extraction and random-effects meta-analyses models were applied. Seven RCTs were include, which studied pharmacological therapy, digital interventions, and/or educational content. The primary meta-analyses demonstrated a statistically significant increase in the odds of achieving 7-day point prevalence abstinence (PPA) (OR 1.52, 95% CI 1.15-2.01, number of participants=3,244, moderate-certainty) and continuous abstinence (OR 2.71, 95% CI 1.31-5.61, number of participants=164, low-certainty) following intervention. A non-significant increase in odds was noted at 30-day PPA (OR 1.32, 95% CI 0.72-2.42, number of participants=1,994, very low certainty).

Conclusion: Vaping cessation interventions increase 7-day PPA rates at 1 to 12 month follow up and this was consistent across pre-specified subgroup analyses of the intervention type, outcome, and duration of follow-up. More high-quality studies with reproducible findings are needed to enhance the certainty of the evidence and guide clinical interventions.