1 ) 34 yr. non-smoking healthy female with LDL 4.1 and 3 siblings with MI under 50 yrs. I. “Forget primary and secondary” targets- Guidelines should adopt universal screening models with 30 yr absolute risk II. Suspected FH and other forms of familial dyslipidemia-“My approach in 2024”
2 ) 45 yr. old active man with chest injury playing hockey, non-smoker with mild hypertension on an ARB, A1C 5.7 and LDL 3.3 had a chest CT with incidental “mild LAD calcification.” I. Approach to subclinical ASCVD and “intermediate risk” a) Role of Lp(a) b) Routine stress testing-low value and should avoid? c) What if “heavy calcification of coronaries & low FRS-“Risk adjustment” required?
Disclosure(s):
Liam R. Brunham, MD PhD FRCPC: Amgen: Consultant/Advisory Board (Ongoing), Research Grant (includes principal investigator, collaborator or consultant and pending grants as well as grants already received) (Ongoing), Speaker/Honoraria (Ongoing); Novartis: Consultant/Advisory Board (Ongoing), Research Grant (includes principal investigator, collaborator or consultant and pending grants as well as grants already received) (Ongoing), Speaker/Honoraria (Ongoing); Ultragenyx: Consultant/Advisory Board (Ongoing), Speaker/Honoraria (Ongoing)
